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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: CD200 in dentate gyrus improves depressive-like behaviors of mice through enhancing hippocampal neurogenesis via alleviation of microglia hyperactivation

Fig. 7

Mechanism diagram for antidepressant effect of CD200 in the dentate gyrus. Under physiological conditions, the interaction of CD200 with CD200R1 maintains microglia in an inactive, homeostatic state. After chronic stress, the reduction of CD200 expression in the DG induces the microglia hyperactivation and then the damage of adult hippocampal neurogenesis, leading to depressive-like behaviors of mice. Upregulation of CD200 levels in the DG inhibits microglia hyperactivation induced by CSDS, and then alleviates adult hippocampal neurogenesis impairment, thereby exerting an antidepressant effect

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Journal of Neuroinflammation

ISSN: 1742-2094