Fig. 7
From: Caudal DMN neurons innervate the spleen and release CART peptide to regulate neuroimmune function
CARTp can reduce inflammation independent of nicotinic cholinergic receptors. A Summary data showing that IL-1ß levels are significantly enhanced in splenocyte culture media in response to LPS. CARTp treatment significantly reduced IL-1ß levels. B Summary data showing that the LPS-mediated increase in IL-1ß in RAW264.7 cell media (n = 5/group) is significantly reduced by treatment with CARTp, but not by the control scrambled CART peptide. Ø, no treatment. C Summary results showing that treatment with the nicotinic acetylcholine receptor blocker α-bungarotoxin blocked the anti-inflammatory effect of acetylcholine, but was ineffective at blocking the effect of CARTp treatment. This suggests that CARTp can reduced inflammation independent of nicotinic cholinergic receptors