Fig. 1
From: Neuroprotective effects of GSK-343 in an in vivo model of MPTP-induced nigrostriatal degeneration
Effect of GSK-343 on behavioral impairments induced by MPTP. Mice subjected to MPTP injection showed a significant increase in behavioral deficits compared to the Sham group (A–D). Contrarily, GSK-343, at the two highest doses, considerably decreases “Time to turn” and “Time in closed arms” (A–D). Sham + GSK-343 administered groups were comparable to Sham mice (A–D). Data are representative of at least three independent experiments. Values are means ± SEM. One-way ANOVA test. ***p < 0.001 vs Sham; #p < 0.05 vs MPTP; ##p < 0.01 vs MPTP; ###p < 0.001 vs MPTP