Fig. 2
From: Neuroprotective effects of GSK-343 in an in vivo model of MPTP-induced nigrostriatal degeneration
Effect of GSK-343 treatment on TH expression. MPTP mice exhibited an extensive loss of TH-positive neurons (B, B1, score F), compared to the Sham group (A, A1, score F). GSK-343 1 mg/kg did not reduce the loss TH-positive neurons (C, C1, score F). GSK-343 5 mg/kg treatment, and especially at the dose of 10 mg/kg, restored the numbers of TH + neurons (D, D1; E, E1, score F). Data are representative of at least three independent experiments. Values are means ± SEM. One-way ANOVA test. ***p < 0.001 vs Sham; ###p < 0.001 vs MPTP