Fig. 9
From: Neuroprotective effects of GSK-343 in an in vivo model of MPTP-induced nigrostriatal degeneration
Effect of GSK-343 on pro-inflammatory enzymes and MMPs. Representative blots of iNOS, COX-2 revealed a significant upregulation of these markers in MPTP-injected mice compared to Sham mice. These expressions were considerably reduced following GSK-343 treatment (A, B; densitometric analysis A1–B1). MMP2 and MMP9 levels were increased in MPTP-intoxicated mice, while GSK-343 administration was able to reduce their levels (C, D; densitometric analysis C1, D1). Data are representative of at least three independent experiments. Values are means ± SEM. One-way ANOVA test. ***p < 0.001 vs Sham; ###p < 0.001 vs MPTP