Fig. 1

Experimental schematic diagram. Perioperative neurocognitive disorders (PND) were established by tibial fracture surgery (TF) in aged mice. At 8 days after TF exposure, open field test (OFT), elevated plus maze (EPM), and the first stage of fear conditioning (FC) were performed. At 9 days after TF exposure, the second stage of FC was performed. At 10 days after TF exposure, the immunofluorescence (IF) and western blot assay (WB) experiments were performed. Selegiline was administered from postoperative day 0 to 7 once a day. An equal volume of normal saline was used as vehicle