Fig. 5

The imbalance between excitatory and inhibitory neurons can be restored by selegiline administration. A Representative photomicrographs of GFAP-, NeuN-, VGLUT2-, GAD65-, GABA- and glutamate-positive cells in the CA1 of hippocampus at 10 days after surgical exposure. Scale bar = 50 μm. B Image of CA1 in hippocampus. C–F The intensity of GFAP, NeuN, VGLUT2, and GAD65 was quantified in each group. G, H Co-stained area of GABA- and GFAP-positive cells, and glutamate- and GFAP-positive cells in the CA1 of hippocampus. I Representative western blot of IL-1β, IL-18, MAP2, and PSD95. J–M The optical density values of IL-1β, IL-18, MAP2, and PSD95. Data are presented as the mean ± SD (n = 6 mice/group). Data were analyzed by one-way ANOVA with Tukey’s multiple comparison test or Kruskal–Wallis and Dunn’s multiple comparison test. ****P < 0.0001; ***P < 0.001; **P < 0.01; *P < 0.05