Fig. 7

Astrocyte-specific NLRP3 knockout ameliorates impulsive-like behaviors and cognitive impairment post-surgery. A Breeding scheme for GFAP-Cre mice crossed with NLRP3-cKO mice and gene strategy for preparing NLRP3-conditional knockout (cKO) mice. B Representative genotyping analysis for NLRP3-cKO homozygote, NLRP3-cKO heterozygote, and WT (wild type) mice and NLRP3-cKO homozygote, NLRP3-cKO heterozygote, GFAP-Cre, non-GFAP-Cre F4 mice. C Computer printouts showing the shifting trajectories of each group in the OFT at 8 days after surgical exposure. D Computer printouts showing the shifting trajectories of each group in the EPM at 8 days after surgical exposure. E The total distance for each group at 8 days after surgical exposure. F The time spent in the open arm for each group at 8 days after surgical exposure. G The freezing time caused by the indicated stimuli during the FC test results. Data are presented as the mean ± SD (n = 12 mice/group). Data were analyzed by one-way ANOVA with Tukey’s multiple comparison test or Kruskal–Wallis and Dunn’s multiple comparison test. ****P < 0.0001; *P < 0.05