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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Disease-modifying effects of a glial-targeted inducible nitric oxide synthase inhibitor (1400W) in mixed-sex cohorts of a rat soman (GD) model of epilepsy

Fig. 2

1400W significantly reduced soman-induced motor deficit, measured by rotarod, in mixed-sex cohort (A). Experimental design for the Novel Object Recognition (NOR) test (B) and representative heatmap from each group during 24 h probe testing (C). 1400W significantly rescued soman-induced long-term memory deficits at 24 h post-familiarization (E) but not at 3 h (D). No sex interaction was detected in either rotarod or NOR test either at 3 h or 24 h. A, D, E Two-way ANOVA (Tukey’s multiple comparisons test), n = 16–26 for mixed-sex cohort (8–13/sex). *p < 0.05, **p < 0.01 vs control; #p < 0.05, ##p < 0.01 vs Soman + vehicle

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