From: Emerging role of non-coding RNAs in neuroinflammation mediated by microglia and astrocytes
 | ncRNAs | Target | Function |
---|---|---|---|
AD | miR-22↑ |  | Improve neurological function and neuroinflammation [28] |
AD | miR-146a↑ | TRAF6 | Led to synaptogenesis and correction of cognitive impairment [29] |
AD | miR-155↑ | SOCS1 | Contributes to neuroinflammation [30] |
AD | let-7b↑ | TLR7 | Promotes microglia activation [31] |
AD | miR-592↑ | KIAA0319 | Promotes oxidative stress injury [32] |
AD | miR-135a↑ | Thrombospondin 1 | Promotes neuronal apoptosis [33] |
AD | miR-206↑ | IGF1 | Induces inflammation and Aβ release in microglia [34] |
AD | miR-34a↓ | TREM2 | Inhibits the ability of microglia to catabolize Aβ42 [35] |
AD | miR-155↑ |  | Promotes the ability of microglia to catabolize Aβ42 [36] |
AD | miR-331-3p | Sequestosome 1 | Ameliorates Alzheimer's disease by enhancing autophagy [37] |
AD | miR-9-5p | Optineurin | Ameliorates Alzheimer's disease by enhancing autophagy [37] |
AD | miR-138↑ | Sirt1 | Contributes to Aβ42 production and neuroinflammation [38] |
AD | lncMEG3↓ | PI3K/Akt | Improves cognitive impairment, alleviates neuronal damage [39] |
AD | lncUCA1↑ | miR-1/Hes1 | Regulates neural stem cell differentiation [40] |
AD | circNF1-419↑ | Dynamin-1, AP2B1 | Enhances astrocytes autophagy to ameliorate senile dementia [41] |
PD | miR-155↑ |  | Promotes microgliosis and proinflammatory response [48] |
PD | miR-7116-5p↓ | TNF-α | Suppresses TNF-α production and inflammatory responses [49] |
PD | miR-335↓ | LRRK2 | Alleviates inflammatory responses [50] |
PD | miR-124↓ | MEKK3 | Attenuates microglia activation and neuroinflammation [51] |
PD | miR-124↓ | p38, p62 | Attenuates microglia activation and neuroinflammation [52] |
PD | miR-3473b↑ | TREM2 | Promotes the activation of microglia and inhibits autophagy [53] |
PD | miR-19a-3p↑ | PTEN/AKT/mTOR | Suppress autophagy in recipient microglia [54] |
PD | miR-7↓ | NLRP3 | Modulates NLRP3 inflammasome-mediated inflammation [55] |
PD | lncSNHG1↑ | miR-7/NLRP3 | Promotes microglia activation and NLRP3 inflammasome [56] |
PD | lncGAS5↑ | miR-223-3p/NLRP3 | Promotes microglial inflammatory response [57] |
PD | lncMALAT1↑ | EZH2/NRF2 | Promotes inflammasome activation and ROS production [58] |
PD | lncHOXA11-AS↑ | miR-124-3p/FSTL1 | Enhances microglia activation and neurological damages [59] |
PD | lincRNA-p21↑ | miR-181/PKC-δ | Facilitates sustained microglial activation [60] |
ALS | miR-155↑ |  | Promotes dysfunctional microglia and deteriorate disease [65] |
ALS | miR-125b↑ | A20 | Promotes microglia activation and motor neuron death [66] |
ALS | miR-146a↓ | IRAK1, TRAF6 | Reverts astrocytes aberrancies [67] |
ALS | miR-124↓ | Sox2, Sox9 | Modulates astrocytic differentiation of neural stem cells [68] |
ALS | miR-494-3p↓ | SEMA3A | Increases MN survival [70] |
ALS | miR-218↑ | EAAT2 | Promotes astrogliosis [71] |
MS | miR-155↑ | CD47 | Promote neuroinflammation [75] |
MS | miR-155↑ | SOCS1 | Promotes inflammatory responses in microglia and astrocytes [77] |
MS | miR-155↑ | Annexin-2, Claudin-1, DOCK-1, Syntenin-1 | Negatively regulates BBB function [78] |
MS | miR-146a↑ | IRAK1 | Promotes OPC differentiation and enhances remyelination [79] |
MS | miR-146a↑ | Syt1, Nlg1 | Decreases density of dendritic spines and excitatory synapses [80] |
MS | miR-223↑ | ATG16L1 | Suppresses autophagy and promotes CNS inflammation [81] |
MS | miR-223↑ | RASA1 | Promotes regenerative myeloid cell phenotype and function [82] |
MS | miR-124↓ | C/EBP-α-PU.1 | Promotes microglia quiescence and suppresses EAE [83] |
MS | miR-30a↑ | Ppargc1b | Promotes microglial inflammatory response and aggravates EAE [84] |
MS | miR-23b↓ | TAB2, TAB3, IKK-α | Suppresses IL-17-associated autoimmune inflammation [86] |
MS | miR-873↑ | A20/NF-κB | Contributes to the inflammatory response and EAE pathogenesis [87] |
MS | miR-409-3/1896↑ | SOCS3/STAT3 | Promotes inflammatory cytokine production and EAE pathogenesis [88] |
MS | lncGm13568↑ | CBP/P300 | Contributes to the pathogenesis of EAE [89] |
MS | lncGAS5↓ | PRC2 | Inhibits microglial M2 polarization and exacerbates demyelination [90] |
MS | lncHOTAIR↓ | miR-136-5p/AKT2 | Promotes M1 microglial polarization and suppresses remyelination [91] |