Fig. 2

Frequencies of B-cell subpopulations across the study groups. Eight subsets of CD19⁺ cells were measured by flow cytometry as shown in Additional file 1: Fig. S1. In addition to the individual data points, the medians and interquartile ranges per group are depicted by box plots. The brackets indicate statistical significance in pairwise comparisons based on Tukey post hoc tests for linear mixed-effects models. The average percentages per group are given in Additional file 3. IRT = immune reconstitution therapy, PPMS = primary progressive multiple sclerosis, * p < 0.05, ** p < 0.01, *** p < 0.001