Fig. 4
From: Chemogenetic activation of locus coeruleus neurons ameliorates the severity of multiple sclerosis
The effect of early chronic chemogenetic LC activation on noradrenergic projections. Representative images showing DBH-positive fibers in the A dorsal and B ventral horns (DH, VH) of the lumbar spinal cord, D PL/IL and F M2/M1 cortices, and C, E, G the quantification of DBH immunoreactivity (IR) in arbitrary units (AU). The data represent the mean + SEM and each point corresponds to an individual mouse (n = 4–5 per group). #p < 0.05, ###p < 0.001 EAE versus naïve; *p < 0.05, **p < 0.01, EAE-rM3Donset versus EAE (Additional file 1: Table S5). Scale bars: A, B, D, F, 100 µm