Fig. 8
Improved retinal function in mice after anti-CD8 treatment. a–e Representative scotopic and photopic ERGs recorded with increasing light intensities from dark-adapted untreated and anti-CD8-treated C57BL/6 mice. a Scotopic traces on day 14 (black) superimposed on electroretinograms of day 1 of untreated and anti-CD8-treated retinas. b, c Shown are mean ± SD of scotopic a- (b) and b-wave (c) amplitudes. d Photopic traces on day 14 (black) superimposed on electroretinograms of day 1 of untreated and CD8-treated retinas. e Shown are mean ± SD (n = 4–5) of photopic b-wave (e) amplitudes. For both groups, day 0 was used as calibrator [NRQ (normalized relative quantification) = 1]. Significant differences (*p < 0.1, **p < 0.01, ***p < 0.001 and ****p < 0.0001) between untreated and CD8-treated mica were determined by using a t-test (n = 4–5)