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Table 1 Effect of ethanol on LPS-induced mRNA expression of proinflammatory cytokines in brain

From: Exacerbating effects of single-dose acute ethanol exposure on neuroinflammation and amelioration by GPR110 (ADGRF1) activation

Wild type

GPR110 KO

LPS-induced fold changea

LPS-induced fold change

Cytokine

Maltose

Ethanol

p-valueb

Maltose

Ethanol

p-value

TNF-α

12.21 ± 3.66

58.25 ± 9.23

3.33E−02

14.64 ± 3.50

52.86 ± 6.24

3.98E−05

IL-6

14.46 ± 3.56

25.71 ± 7.36

3.33E−02

14.47 ± 3.56

36.11 ± 6.78

1.31E−03

IL-1β

40.14 ± 8.74

102.57 ± 26.74

8.08E−03

19.75 ± 4.10

129.58 ± 11.73

2.11E−06

NLRP3

4.80 ± 0.69

7.48 ± 1.51

8.10E−02

6.70 ± 0.85

31.85 ± 2.70

1.92E−06

AC8

0.51 ± 0.05

0.21 ± 0.02

7.41E−05

0.51 ± 0.10

0.24 ± 0.06

5.76E−03

PDE4B

1.77 ± 0.29

2.47 ± 0.24

2.70E−02

2.22 ± 0.34

4.82 ± 0.56

1.51E−04

  1. aRelative to maltose control without LPS injection
  2. bCalculated by Student’s t-test for fold changes of Ethanol + LPS vs. Maltose + LPS (n = 4)
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Journal of Neuroinflammation

ISSN: 1742-2094