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Table 2 Effect of ethanol on LPS-induced expression of proinflammatory proteins in brain

From: Exacerbating effects of single-dose acute ethanol exposure on neuroinflammation and amelioration by GPR110 (ADGRF1) activation

Wild type

GPR110 KO

POI/GAPDH

POI/GAPDH

Protein

Maltose

Ethanol

p-valuea

Maltose

Ethanol

p-value

NLRP3

0.27 ± 0.11

0.67 ± 0.10

1.02E−02

1.09 ± 0.05

1.53 ± 0.15

9.00E−04

IL-1β

0.90 ± 0.04

1.39 ± 0.18

1.00E−02

0.78 ± 0.13

1.60 ± 0.11

1.00E−03

Iba-1

0.97 ± 0.01

2.18 ± 0.07

7.86E−06

1.37 ± 0.17

1.97 ± 0.45

1.00E−01

PDE4B

1.06 ± 0.07

1.40 ± 0.20

5.00E−02

1.00 ± 0.10

1.40 ± 0.26

7.00E−02

  1. POI protein of interest
  2. aCalculated by Student’s t-test for Ethanol + LPS vs. Maltose + LPS group (n = 3)
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Journal of Neuroinflammation

ISSN: 1742-2094