Fig. 1

Illustrations and quantification of the immunostaining of Aβ (4G8) and pTau (AT8) expressed as protein load (%) in the temporal cortex (TL: A–F) and cerebellar cortex (Cb: G–L). Significant increases over the course of the disease are observed for Aβ (P < 0.0001) and pTau (P < 0.0001) in the temporal cortex and for Aβ (P = 0.0008) in the cerebellar cortex. No change was detected for pTau in the cerebellum. Counterstaining: Haematoxylin. Scale bar = 50μm