The mitochondrial protein TSPO in Alzheimer’s disease: relation to the severity of AD pathology and the neuroinflammatory environment

Garland, Emma F.; Dennett, Oliver; Lau, Laurie C.; Chatelet, David S.; Bottlaender, Michel; Nicoll, James A. R.; Boche, Delphine

doi:10.1186/s12974-023-02869-9

Journal of Neuroinflammation

Table 4 Correlations between pathological/microglial proteins and inflammatory markers across all Braak stages in the temporal lobe

From: The mitochondrial protein TSPO in Alzheimer’s disease: relation to the severity of AD pathology and the neuroinflammatory environment

	Aβ	pTau	TSPO	Iba1	HLA–DR	MSR-A
GM-CSF	r_s = − 0.145 P = 0.312	r_s = − 0.230 P = 0.111	r_s = − 0.355 P < 0.01	r_s = − 0.154 P = 0.280	r_s = − 0.088 P = 0.554	r_s = − 0.023 P = 0.875
IL1α	r_s = 0.098 P = 0.0499	r_s = − 0.025 P = 0.863	r_s = − 0.136 P = 0.337	r_s = − 0.103 P = 0	r_s = 0.017 P = 0.910	r_s = − 0.065 P = 0.652
IL12/IL23p70	r_s = − 0.104 P = 0.472	r_s = − 0.192 P = 0.187	r_s = − 0.105 P = 0.458	r_s = 0.060 P = 0.676	r_s = 0.201 P = 0.176	r_s = − 0.084 P = 0.560
IL15	r_s = 0.123 P = 0.393	r_s = 0.268 P = 0.063	r_s = 0.310 P = 0.025	r_s = − 0.094 P = 0.513	r_s = − 0.005 P = 0.971	r_s = 0.044 P = 0.757
IL16	r_s = 0.039 P = 0.786	r_s = 0.060 P = 0.682	r_s = 0.155 P = 0.274	r_s = 0.267 P = 0.059	r_s = 0.202 P = 0.174	r_s = − 0.161 P = 0.260
IL17A	r_s = 0.016 P = 0.915	r_s = 0.206 P = 0.156	r_s = 0.134 P = 0.344	r_s = − 0.145 P = 0.310	r_s = − 0.239 P = 0.106	r_s = − 0.154 P = 0.280
IL5	r_s = − 0.117 P = 0.417	r_s = − 0.053 P = 0.718	r_s = − 0.107 P = 0.451	r_s = 0.091 P = 0.523	r_s = 0.160 P = 0.283	r_s = − 0.009 P = 0.947
IL7	r_s = − 0.297 P = 0.036	r_s = − 0.285 P = 0.047	r_s = − 0.013 P = 0.925	r_s = − 0.123 P = 0.390	r_s = 0.144 P = 0.334	r_s = 0.004 P = 0.979
TNFβ	r_s = − 0.069 P = 0.632	r_s = − 0.175 P = 0.229	r_s = 0.042 P = 0.767	r_s = − 0.065 P = 0.649	r_s = − 0.007 P = 0.962	r_s = − 0.021 P = 0.883
VEGF	r_s = − 0.310 P = 0.028	r_s = − 0.081 P = 0.578	r_s = − 0.188 P = 0.182	r_s = 0.010 P = 0.945	r_s = 0.170 P = 0.254	r_s = 0.152 P = 0.286
Eotaxin	r_s = 0.005 P = 0.974	r_s = 0.207 P = 0.153	r_s = 0.019 P = 0.895	r_s = 0.063 P = 0.662	r_s = − 0.256 P = 0.083	r_s = − 0.092 P = 0.520
Eotaxin 3	r_s = 0.0003 P = 0.998	r_s = 0.110 P = 0.451	r_s = − 0.014 P = 0.923	r_s = − 0.106 P = 0.461	r_s = − 0.209 P = 0.158	r_s = 0.001 P = 0.993
IL8 (HA)	r_s = − 0.176 P = 0.220	r_s = 0.092 P = 0.531	r_s = 0.067 P = 0.639	r_s = 0.016 P = 0.914	r_s = − 0.156 P = 0.296	r_s = 0.036 P = 0.800
IP10	r_s = 0.051 P = 0.725	r_s = 0.192 P = 0.186	r_s = 0.149 P = 0.293	r_s = 0.251 P = 0.075	r_s = 0.018 P = 0.906	r_s = 0.059 P = 0.682
MCP1	r_s = 0.186 P = 0.196	r_s = 0.342 P = 0.016	r_s = 0.119 P = 0.400	r_s = 0.072 P = 0.614	r_s = − 0.054 P = 0.718	r_s = − 0.003 P = 0.986
MCP4	r_s = − 0.0004 P = 0.998	r_s = 0.250 P = 0.083	r_s = 0.335 P = 0.015	r_s = − 0.084 P = 0.557	r_s = − 0.219 P = 0.139	r_s = − 0.081 P = 0.574
MDC	r_s = 0.011 P = 0.942	r_s = 0.250 P = 0.084	r_s = 0.152 P = 0.281	r_s = − 0.070 P = 0.624	r_s = − 0.381 P = 0.007	r_s = − 0.003 P = 0.982
MIP1α	r_s = 0.002 P = 0.991	r_s = 0.250 P = 0.084	r_s = 0.054 P = 0.702	r_s = 0.060 P = 0.675	r_s = − 0.150 P = 0.315	r_s = 0.002 P = 0.990
MIP1β	r_s = − 0.188 P = 0.192	r_s = 0.103 P = 0.479	r_s = − 0.010 P = 0.944	r_s = 0.021 P = 0.883	r_s = − 0.140 P = 0.350	r_s = − 0.026 P = 0.854
TARC	r_s = − 0.015 P = 0.919	r_s = 0.046 P = 0754	r_s = − 0.177 P = 0.209	r_s = 0.0005 P = 0.970	r_s = − 0.075 P = 0.618	r_s = 0.008 P = 0.957
IFNγ	r_s = − 0.030 P = 0.835	r_s = − 0.005 P = 0.971	r_s = − 0.123 P = 0.386	r_s = 0.032 P = 0.821	r_s = 0.019 P = 0.897	r_s = 0.141 P = 0.325
IL1β	r_s = − 0.121 P = 0.401	r_s = 0.039 P = 0.791	r_s = − 0.088 P = 0.537	r_s = 0.088 P = 0.537	r_s = − 0.005 P = 0.974	r_s = − 0.025 P = 0.864
IL10	r_s = − 0.086 P = 0.550	r_s = 0.049 P = 0.741	r_s = − 0.168 P = 0.233	r_s = − 0.023 P = 0.873	r_s = − 0.128 P = 0.391	r_s = − 0.058 P = 0.684
IL12p70	r_s = − 0.163 P = 0.258	r_s = − 0.049 P = 0.739	r_s = 0.027 P = 0.850	r_s = − 0.236 P = 0.095	r_s = − 0.169 P = 0.255	r_s = 0.002 P = 0.990
IL13	r_s = − 0.169 P = 0.241	r_s = − 0.016 P = 0.914	r_s = 0.000 P = 0.999	r_s = − 0.273 P = 0.053	r_s = − 0.255 P = 0.084	r_s = 0.155 P = 0.276
IL2	r_s = − 0.142 P = 0.324	r_s = − 0.095 P = 0.515	r_s = − 0.134 P = 0.345	r_s = − 0.061 P = 0.669	r_s = − 0.122 P = 0.413	r_s = 0.126 P = 0.337
IL4	r_s = − 0.229 P = 0.110	r_s = 0.016 P = 0.912	r_s = 0.072 P = 0.614	r_s = − 0.125 P = 0.382	r_s = − 0.111 P = 0.458	r_s = 0.159 P = 0.266
IL6	r_s = − 0.008 P = 0.958	r_s = 0.033 P = 0.820	r_s = 0.063 P = 0.655	r_s = 0.032 P = 0.823	r_s = − 0.057 P = 0.704	r_s = 0.115 P = 0.421
IL8	r_s = − 0.121 P = 0.401	r_s = 0.008 P = 0.954	r_s = − 0.031 P = 0.827	r_s = 0.000 P = 0.998	r_s = − 0.322 P = 0.027	r_s = − 0.025 P = 0.860
TNFα	r_s = − 0.273 P = 0.055	r_s = − 0.103 P = 0.480	r_s = − 0.118 P = 0.406	r_s = − 0.054 P = 0.708	r_s = − 0.221 P = 0.135	r_s = − 0.021 P = 0.883

r_s Spearman’s rank correlation, significant P values in bold

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ISSN: 1742-2094

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