The mitochondrial protein TSPO in Alzheimer’s disease: relation to the severity of AD pathology and the neuroinflammatory environment

Garland, Emma F.; Dennett, Oliver; Lau, Laurie C.; Chatelet, David S.; Bottlaender, Michel; Nicoll, James A. R.; Boche, Delphine

doi:10.1186/s12974-023-02869-9

Journal of Neuroinflammation

Table 5 Correlations between the pathological/microglial proteins and inflammatory markers across all Braak stages in the cerebellum

From: The mitochondrial protein TSPO in Alzheimer’s disease: relation to the severity of AD pathology and the neuroinflammatory environment

	Aβ	pTau	TSPO	Iba1	HLA–DR	MSR-A
GM-CSF	r_s = 0.114 P = 0.556	r_s = − 0.163 P = 0.398	r_s = − 0.237 P = 0.196	r_s = 0.031 P = 0.873	r_s = 0.049 P = 0.802	r_s = 0.136 P = 0.498
IL1α	r_s = 0.060 P = 0.674	r_s = 0.014 P = 0.920	r_s = − 0.121 P = 0.392	r_s = 0.086 P = 0.546	r_s = − 0.189 P = 0.179	r_s = 0.037 P = 0.800
IL12/IL23p70	r_s = 0.006 P = 0.969	r_s = − 0.074 P = 0.622	r_s = − 0.037 P = 0.807	r_s = 0.333 P = 0.022	r_s = − 0.194 P = 0.191	r_s = − 0.069 P = 0.654
IL15	r_s = − 0.005 P = 0.974	r_s = 0.184 P = 0.193	r_s = 0.241 P = 0.086	r_s = 0.151 P = 0.286	r_s = − 0.118 P = 0.403	r_s = 0.079 P = 0.584
IL16	r_s = 0.189 P = 0.179	r_s = − 0.001 P = 0.992	r_s = 0.121 P = 0.391	r_s = 0.438 P < 0.001	r_s = 0.034 P = 0.810	r_s = − 0.018 P = 0.902
IL17A	r_s = − 0.180 P = 0.202	r_s = − 0.025 P = 0.863	r_s = 0.058 P = 0.682	r_s = 0.075 P = 0.599	r_s = − 0.239 P = 0.088	r_s = − 0.011 P = 0.941
IL5	r_s = 0.255 P = 0.094	r_s = 0.004 P = 0.982	r_s = − 0.364 P = 0.015	r_s = 0.053 P = 0.733	r_s = − 0.177 P = 0.249	r_s = 0.005 P = 0.976
IL7	r_s = − 0.223 P = 0.464	r_s = 0.083 P = 0.789	r_s = 0.586 P = 0.035	r_s = 0.270 P = 0.372	r_s = 0.193 P = 0.528	r_s = − 0.182 P = 0.571
TNFβ	r_s = − 0.296 P = 0.049	r_s = − 0.199 P = 0.189	r_s = − 0.088 P = 0.567	r_s = 0.172 P = 0.260	r_s = − 0.220 P = 0.146	r_s = − 0.059 P = 0.709
VEGF	r_s = − 0.063 P = 0.655	r_s = − 0.088 P = 0.537	r_s = − 0.206 P = 0.142	r_s = − 0.070 P = 0.622	r_s = − 0.229 P = 0.102	r_s = − 0.096 P = 0.507
Eotaxin	r_s = − 0.129 P = 0.361	r_s = − 0.206 P = 0.142	r_s = − 0.226 P = 0.108	r_s = 0.177 P = 0.209	r_s = − 0.212 P = 0.131	r_s = − 0.127 P = 0.379
Eotaxin 3	r_s = 0.058 P = 0.681	r_s = − 0.097 P = 0.493	r_s = − 0.077 P = 0.588	r_s = − 0.156 P = 0.269	r_s = 0.014 P = 0.922	r_s = 0.109 P = 0.449
IL8 (HA)	r_s = − 0.089 P = 0.532	r_s = 0.060 P = 0.673	r_s = − 0.023 P = 0.870	r_s = 0.056 P = 0.692	r_s = − 0.316 P = 0.023	r_s = 0.041 P = 0.775
IP10	r_s = − 0.059 P = 0.679	r_s = − 0.082 P = 0.563	r_s = 0.059 P = 0.680	r_s = − 0.036 P = 0.799	r_s = − 0.016 P = 0.911	r_s = 0.040 P = 0.783
MCP1	r_s = − 0.117 P = 0.410	r_s = − 0.043 P = 0.760	r_s = − 0.090 P = 0.524	r_s = 0.058 P = 0.658	r_s = − 0.151 P = 0.287	r_s = 0.129 P = 0.373
MCP4	r_s = − 0.153 P = 0.280	r_s = − 0.158 P = 0.264	r_s = − 0.166 P = 0.240	r_s = 0.148 P = 0.295	r_s = − 0.222 P = 0.114	r_s = − 0.099 P = 0.495
MDC	r_s = − 0.135 P = 0.341	r_s = − 0.015 P = 0.916	r_s = − 0.083 P = 0.557	r_s = 0.143 P = 0.311	r_s = − 0.233 P = 0.096	r_s = 0.049 P = 0.734
MIP1α	r_s = − 0.137 P = 0.332	r_s = − 0.144 P = 0.308	r_s = − 0.184 P = 0.191	r_s = 0.184 P = 0.191	r_s = − 0.253 P = 0.070	r_s = − 0.124 P = 0.389
MIP1β	r_s = − 0.299 P = 0.031	r_s = − 0.175 P = 0.215	r_s = − 0.193 P = 0.171	r_s = 0.119 P = 0.402	r_s = − 0.238 P = 0.090	r_s = 0.006 P = 0.969
TARC	r_s = − 0.303 P = 0.029	r_s = − 0.074 P = 0.603	r_s = − 0.169 P = 0.231	r_s = − 0.008 P = 0.957	r_s = − 0.142 P = 0.316	r_s = − 0.106 P = 0.463
IFNγ	r_s = 0.010 P = 0.946	r_s = − 0.227 P = 0.113	r_s = 0.164 P = 0.257	r_s = 0.336 P = 0.017	r_s = − 0.165 P = 0.251	r_s = − 0.150 P = 0.310
IL1β	r_s = − 0.099 P = 0.485	r_s = 0.028 P = 0.843	r_s = 0.070 P = 0.620	r_s = 0.011 P = 0.940	r_s = 0.058 P = 0.681	r_s = 0.178 P = 0.216
IL10	r_s = 0.014 P = 0.924	r_s = − 0.226 P = 0.107	r_s = − 0.061 P = 0.667	r_s = 0.321 P = 0.020	r_s = − 0.238 P = 0.089	r_s = 0.026 P = 0.858
IL12p70	r_s = − 0.042 P = 0.765	r_s = − 0.232 P = 0.098	r_s = − 0.111 P = 0.432	r_s = 0.287 P = 0.039	r_s = − 0.130 P = 0.360	r_s = − 0.019 P = 0.895
IL13	r_s = − 0.129 P = 0.361	r_s = − 0.146 P = 0.301	r_s = − 0.311 P = 0.025	r_s = − 0.137 P = 0.333	r_s = − 0.225 P = 0.108	r_s = − 0.010 P = 0.947
IL2	r_s = − 0.031 P = 0.829	r_s = − 0.242 P = 0.087	r_s = − 0.076 P = 0.596	r_s = 0.340 P = 0.015	r_s = − 0.244 P = 0.084	r_s = − 0.050 P = 0.734
IL4	r_s = 0.122 P = 0.387	r_s = − 0.030 P = 0.834	r_s = − 0.006 P = 0.968	r_s = 0.192 P = 0.174	r_s = − 0.196 P = 0.163	r_s = − 0.104 P = 0.473
IL6	r_s = − 0.063 P = 0.659	r_s = 0.032 P = 0.823	r_s = 0.048 P = 0.736	r_s = 0.055 P = 0.699	r_s = − 0.053 P = 0.711	r_s = 0.174 P = 0.228
IL8	r_s = 0.006 P = 0.967	r_s = 0.029 P = 0.836	r_s = − 0.092 P = 0.519	r_s = − 0.031 P = 0.829	r_s = − 0.098 P = 0.491	r_s = 0.159 P = 0.271
TNFα	r_s = − 0.143 P = 0.312	r_s = − 0.237 P = 0.091	r_s = − 0.200 P = 0.154	r_s = 0.276 P = 0.047	r_s = − 0.163 P = 0.247	r_s = − 0.052 P = 0.719

r_s Spearman’s rank correlation, significant P values in bold

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ISSN: 1742-2094

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