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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Repeated closed-head mild traumatic brain injury-induced inflammation is associated with nociceptive sensitization

Fig. 3

Repeated mTBI produced prolonged increase in caspase-1 activation reporter bioluminescence intensity in the brain and hindpaw area of mTBI mice up to at least one week after the last injury, in vivo. A Sample images show caspase-1 activation reporter mouse bioluminescence signals at 1 day, 3 days, 1 week, and 1 month after the last injury. The analyzed ROIs (red circles) were quantified across all time points. B, C Significantly elevated brain and paw caspase-1 activation-associated signals in injured mice were detected 1 day and sustained up to at least 1 week after the last injury (n = 20–24 mice per group; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, repeated-ANOVA, Tukey’s HSD)

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Journal of Neuroinflammation

ISSN: 1742-2094