Cortical superficial siderosis is associated with reactive astrogliosis in cerebral amyloid angiopathy

Table 2 Associations between density of iron deposits and GFAP-positive cells

	Null model	Model including iron deposit density
Age at death (years)
Estimate 95% Confidence interval p-value	51.95 [− 101.49, 204.54] p = 0.491	70.15 [− 82.38, 221.87] p = 0.352
Sex
Estimate 95% Confidence interval p-value	1679 [− 704, 4010] p = 0.157	2106 [− 260, 4436] p = 0.080
Density of iron deposits (objects/mm²)
Estimate 95% Confidence interval p-value		0.2440 [0.0806, 0.4041] p = 0.003
Log Likelihood	− 605.4	− 601.3
AIC	1223	1217
BIC	1236	1232
Total R²	0.49	0.61

Summary of the LME model explaining the density of GFAP-positive cells. Age at death, sex, and density of iron deposits were set as fixed effects; subject and cortical region were set as random effects. An estimate and confidence interval for each of the fixed effects is detailed for each model, along with statistical significance. Significant effects and overall statistics for the best model are in bold. The AIC (Akaike information criterion) and BIC (Bayesian information criterion) are measures of model fit that take model complexity into account. A lower AIC and BIC indicate a better model

ISSN: 1742-2094