Fig. 6

Hyperoxia modulates developmental pathways in the hippocampus of WT animals. A Volcano plot of genes differentially expressed in the hippocampus of room air-exposed WT mice compared to hyperoxia-exposed WT mice (fold change > 1.25 and FDR < 0.1). B Gene set enrichment analysis for Gene Ontology term and KEGG pathways of genes differentially expressed by hyperoxia-exposed WT mice. Hyperoxia-induced genes were associated with neuroprojection morphogenesis, neuron differentiation, neuron development, axonogenesis, blood circulation, HIF-1 pathway, cell growth, chemotaxis, angiogenesis, and vascular development. differentiation, development, and axonogenesis. Hyperoxia-suppressed genes were associated with NGF stimulated transcription, memory, nuclear events kinase and transcription factor activation, short-term memory, response to corticosterone, cell surface receptor signaling pathway involved in cell–cell signaling, ligand-activated transcription factor activity, and response to hypoxia. C Network plot of select top biological processes and their associated genes induced by hyperoxia. D Network plot of select top biological processes and their associated genes suppressed by hyperoxia