Fig. 4
Glutamate and GABA receptors subunit mRNA expression in perilesional cortex. a Box-and-whisker plots with vertical scatter plots of individual cases showing relative fold changes in glutamate receptor subunit gene expression. The gene expression of GRIA2 (GLUR2) was significantly higher in the veh group, as compared with non-lesion controls (t-test, p < 0.001) and the EV group (p = 0.01). b Fold changes of GABA receptor subunit gene expression. The gene expression of GABRD (GABAa ∂) was significantly higher in the EV group as compared with non-lesion controls (t-test, p = 0.004). Gene names: GRIA1 (AMPA GLUR1), GRIA2 (AMPA GLUR2), GRIN1 (NMDA NR1), GRIN2B (NMDA NR2B), GABRA1 (GABAa α1), GABRA2 (GABAa α2), GABRA5 (GABAa α5), GABRD (GABAa ∂), GABBR2 (GABAb R2). Ctr: n = 2; Veh: n = 5; EV: n = 4 monkeys. c MDS plot showing clustering of cases based on mRNA expression profiles of Glu and GABA receptor subunits. The proximity of points indicates the relative similarity-based pair-wise correlation of these multiple mRNA expression variables. Ctr: n = 2; Veh: n = 5; EV: n = 3 monkeys. Box-and-whisker plots: bars show interquartile range and median (horizontal line) with error bars = 95% confidence interval; *p < 0.05, **p < 0.01