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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Sexually dimorphic extracellular vesicle responses after chronic spinal cord injury are associated with neuroinflammation and neurodegeneration in the aged brain

Fig. 5

Validation of Nanostring DEGs with Western blot. Tissue samples from the cortex (A) and hippocampus (B) were processed for Western blot analysis to validate the top DEGs derived from Nanostring. A Expression of the DEG markers PSD95 (Dlg4), NCX1 (Slc8a1), Nefl (Neurofilament Light), and PRAS40 (Akt1s1) in cortex tissue. B Expression of the DEG markers GluN2B (Grin2b), C1qA (C1qa), Nefl, and PKCα (Prkca) in the hippocampus. n = 6 mice/group. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 vs. Sham groups, #p < 0.05, ###p < 0.001 vs. SCI/Male. Two-way ANOVA followed by Tukey’s multiple comparison

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Journal of Neuroinflammation

ISSN: 1742-2094