Fig. 1

Adult deletion of C1q significantly alters Arctic but not WT microbiome. A Experimental overview of study design for adult deletion of C1q. B Alpha diversity is significantly higher in Arc C1q^−/− animals compared to WT C1q^−/− animals at 11–11.5 months of age. C Beta-diversity by Bray–Curtis dissimilarity plotted as PCoA demonstrates deletion of C1q^−/− significantly altered the microbiome of Arctic mice (green vs pink). Symbol color represents individual cages. D Order level taxa bar plots of RosaCre+ WT and Arctic animals with and without C1q. The number of amplicon sequence variants (ASV) for the orders Erysipelotrichales (E) and Clostridiales (F) and the genera Alistipes (of the order Bacteroidales) (G) and Turicibacter (of the order Erysipelotrichales) (H). *p < 0.05; **p < 0.01; ***p < 0.001. ANOVA statistics are available in Additional file 6: Table S1 while beta-diversity PERMANOVA can be found in Additional file 7: Table S2. Additional details are available in Additional file 2