Fig. 3

Cohousing of C5aR1-sufficient and C5aR1KO mice results in microbiome convergence at 5 and 10 months of age. A Schematic of C5aR1KO cohousing study design. B Alpha diversity at 5 months and 10 months. Beta-diversity, as measured by Bray–Curtis dissimilarities at 5 (C) or 10 (D) months are presented as principal component analysis (PCoA) with corresponding PERMANOVA results to right of each graph. Symbol color represents individual cages. Stacked taxa bar plots, collapsed to the order level, detailing the top six most abundant orders present at 5 (E) and 10 (F) months. I, J Examination of order and genus level taxa previously identified in the C5aR1KO separate housing study demonstrated revealed that cohousing eliminated differences in abundance at both ages. *p < 0.05; **p < 0.01; ***p < 0.001. ANOVA statistics are available in Additional file 6: Table S1 while beta-diversity PERMANOVAs can be found in Additional file 6: Table S2. Additional details are available in Additional file 3