Fig. 5

Treatment with PMX205 does not significantly alter the microbiome of Tg2576 mice. A Schematic of the Tg2576 PMX205 study design. Alpha diversity at B 12 months of age, prior to treatment with water or PMX205 or C 15 months of age following 12 weeks of treatment in Tg2576. Beta-diversity, as measured by Bray–Curtis dissimilarities revealed no significant difference between the interaction of genotype and treatment before (C) or after (D) 12 weeks of PMX205 treatment. Stacked taxa bar plots, collapsed to the order level, detailing the top six most abundant orders present before (E) and after (F) PMX205 treatment. G–J Examination of order and genus level taxa from the Arctic PMX205 study. ANOVA statistics are available in Table S1 while beta-diversity PERMANOVA can be found in Additional file 7: Table S2. Additional details are available in Additional file 4