Skip to main content
Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Supraphysiologic doses of 17β-estradiol aggravate depression-like behaviors in ovariectomized mice possibly via regulating microglial responses and brain glycerophospholipid metabolism

Fig. 7

Analysis of untargeted metabolomics of brain from sE2‐treated OVX mice compared to vehicle‐treated OVX mice under positive ions. A Heatmap of 48 significantly changed metabolites based on untargeted metabolomics. B The KEGG enrichment analysis of the differential metabolites. The X-axis indicates the number of annotated metabolites under a given pathway as a percentage of all annotated metabolites. C Matchstick analysis of the differential metabolites. Red boxes are labeled for metabolites related to glycerophospholipid metabolism and retrograde endocannabinoid signaling. ANOVA is performed to determine the significant difference based on P < 0.05 (*), P < 0.01 (**), and P < 0.001 (***), respectively. D Pathway enrichment of differential metabolites. E Network analysis of the differential metabolites. F Heatmap of correlation analysis for differential metabolites. Each group contained 5 animals

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094