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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Supraphysiologic doses of 17β-estradiol aggravate depression-like behaviors in ovariectomized mice possibly via regulating microglial responses and brain glycerophospholipid metabolism

Fig. 8

Under normal physiological conditions, E2 maintains microglial stability, and brain metabolic balance, thereby exerting its neuroprotective effects. The supraphysiological doses of estrogen (sE2) treatment activate the ERα/NF-κB pathway, promote the microglial response and brain metabolic imbalance, and then induce the neuroinflammation-mediated neuronal damage, ultimately resulting in depressive-like behaviors in mice

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Journal of Neuroinflammation

ISSN: 1742-2094