Fig. 1

IRF7 is dispensable for the survival of LGTV infection. WT, Mavs^−/−, Irf3^−/− and Irf7^−/− mice were intraperitoneally infected with 10⁴ FFU of LGTV (n = 10). A Survival and B body weight were monitored. Data represent mean with SEM of n ≥ 10 in each group per time point. Viral burden was determined by quantitative RT-PCR in the serum (C) and spleen (D). The dotted line represents the detection limit. IFN-I levels were determined by bioassay in serum (E) or in the supernatant of infected pDCs (F) or MØ (G). Asterisks indicate statistical significance calculated by Mann–Whitney test (A, C–G) or Student’s t test (B), *p<0.05, **p<0.01. Results are representative for at least two independent experiments