Fig. 8

Cell type-specific antiviral role of IRF7 upon LGTV infection in the brain. Determination of viral titers (A) and IFN-I production (B) from primary hippocampal neuron or whole-brain astrocytes cultures. C Primary astrocytes were transfected with increasing amounts of poly(I:C). Supernatants were harvested 24 h post-transfection and IFN-I was determined by a bioassay. Asterisks indicate statistical significance calculated by Student’s t test, ***p<0.001. Results are representative for at least two independent experiments