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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Neural precursor cell delivery induces acute post-ischemic cerebroprotection, but fails to promote long-term stroke recovery in hyperlipidemic mice due to mechanisms that include pro-inflammatory responses associated with brain hemorrhages

Fig. 3

NPC delivery reduces leukocyte infiltration in the ischemic brain of normolipidemic and hyperlipidemic mice. Total counts and activation states of leukocytes and leukocyte subsets in the brain of mice on normal diet or cholesterol-rich Western diet exposed to MCAO, which were intravenously treated with vehicle or NPCs immediately after reperfusion (as before), followed by animal sacrifice at 48 h. Note the pronounced reduction of myeloid cells (neutrophils, monocytes) and lymphoid cells (CD4+ T cells, NK cells) by NPCs in the ischemic brain of mice on Western diet, in which inflammatory responses were markedly increased compared with mice on normal diet. Data are medians (lines inside boxes)/means (crosses inside boxes) ± interquartile ranges with minimum/maximum values as whiskers. *P < 0.05/**P < 0.01/***P < 0.001 (n = 6 mice for normal diet/vehicle, n = 6 for normal diet/NPC, n = 5 for Western diet/vehicle, n = 7 for Western diet/NPC)

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Journal of Neuroinflammation

ISSN: 1742-2094