Fig. 5

Relationship between B cell receptor characteristics and clinical features. This correlation matrix heatmap illustrates the relationships between the B cell receptor (BCR) characteristics and clinical features in neuromyelitis optica spectrum disorder (NMOSD) (A), myelin oligodendrocyte glycoprotein associated disease (MOGAD) (B), and double-seronegative disease (DSN) (C). Using the vertical and horizontal lines as references, the lower-left quadrant of the matrix represents the correlation between BCR and clinical features, whereas the lower-right quadrant shows the correlation among different BCR characteristics. Statistically significant coefficient R values (p < 0.05) are represented with a red background for positive R values and a blue background for negative R values