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Table 1 Patient characteristics and disease parameters of the cohort

From: Extended interval dosing of ocrelizumab modifies the repopulation of B cells without altering the clinical efficacy in multiple sclerosis

 

All

CG

SID

EID

Individuals

108

28

43

37

Sex (female)

65 (60.18%)

22 (78.57%)

27 (62.79%)

16 (43.24)

Age (mean ± SD)

41.67 ± 11.42

38.89 ± 11.54

41.69 ± 11.93

43.72 ± 10.54

Type of MS

    

 RRMS

84 (77.77%)

23 (82.14%)

35 (81.39%)

26 (70.27%)

 SPMS

4 (3.70%)

0

3 (6.97%)

1 (2.70%)

 PPMS

19 (17.59%)

4 (14.28%)

5 (11.62)

10 (27.02%)

Disease duration (mean ± SD)

10.13 ± 6.95

8.19 ± 6.80

10.79 ± 7.48

10.82 ± 6.29

EDSSa (mean ± SD)

4.09 ± 1.75

3.93 ± 1.74

3.75 ± 1.70

4.39 ± 1.81

Serum NfLb (pg/mL, mean ± SD)

8.51 ± 3.61

9.35 ± 3.13

8.41 ± 4.38

8.44 ± 3.51

Radiological activityc (mean ± SD)

0.76 ± 2.00

2.72 ± 3.28

0.17 ± 0.67*

0.08 ± 0.36*

Number of relapses (mean ± SD)

0.1 ± 0.30

0.32 ± 0.48

0.04 ± 0.22*

0 ± 0*

BMI (mean ± SD)

23.75 ± 3.35

26.65 ± 5.88

24.25 ± 3.39

22.80 ± 2.97

Number of prior OCR infusions (mean ± SD)

NA

NA

3.26 ± 1.03

3.97 ± 1.24

Patients with a follow-up sample:

    

 SID

 

7

23

26

 EID

 

4

19

10

  1. aExpanded disability status scale
  2. bNeurofilament light
  3. cNumber of new lesions close to sampling (± 2 months)
  4. *Significant differences compared to CG