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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Inhibition of neutrophil extracellular trap formation ameliorates neuroinflammation and neuronal apoptosis via STING-dependent IRE1α/ASK1/JNK signaling pathway in mice with traumatic brain injury

Fig. 1

Neutrophils form NETs presenting in the circulation and brain after TBI. A Representative western blot bands of the time course of Ly6G and densitometric quantification of Ly6G after TBI. **p < 0.01, ***p < 0.001, n = 6 per group. B Representative western blot bands of the time course of H3cit and densitometric quantification of H3cit after TBI. **p < 0.01, ***p < 0.001, n = 6 per group. C Quantitative analyses of plasma DNA at 1 day and 3 days after TBI. **p < 0.01, n = 12 per group. D Quantitative analyses of plasma MPO-DNA complexes at 1 day and 3 days after TBI. **p < 0.01, ***p < 0.001, n = 12 per group. E Quantification of MPO activity in the brain of mice at 1 day and 3 days after TBI. ***p < 0.001, n = 12 per group. F Quantitative analyses of cortex MPO-DNA complexes at 1 day and 3 days after TBI. **p < 0.01, ***p < 0.001, n = 12 per group. G Representative images of the colocalization of H3cit (green) with neutrophils (MPO, red) and quantitative analysis of H3cit-positive neutrophils at the lesion site at 1 days and 3 days after TBI. Nuclei were stained with DAPI (blue). Scale bar = 50 μm, ***p < 0.001, n = 6 per group

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Journal of Neuroinflammation

ISSN: 1742-2094