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Fig. 10 | Journal of Neuroinflammation

Fig. 10

From: Inhibition of neutrophil extracellular trap formation ameliorates neuroinflammation and neuronal apoptosis via STING-dependent IRE1α/ASK1/JNK signaling pathway in mice with traumatic brain injury

Fig. 10

Inhibition of IRE1α abolished the neurodestructive effects caused by PAD4 overexpression after TBI. A, B mNSS test (A) and Rotarod test (B) at 1 day post-TBI. *p < 0.05, **p < 0.01, ***p < 0.001, n = 10 per group C, D mNSS test (C) and Rotarod test (D) at 3 days post-TBI. **p < 0.01, ***p < 0.001, n = 10 per group. E Representative western blot bands and densitometric quantification of pIRE1α, pASK1, pJNK, IL-1β, INOs, Arginase-1, Bax, and Bcl-2 after TBI. *p < 0.05, **p < 0.01, ***p < 0.001, n = 6 per group

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Journal of Neuroinflammation

ISSN: 1742-2094