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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Inhibition of neutrophil extracellular trap formation ameliorates neuroinflammation and neuronal apoptosis via STING-dependent IRE1α/ASK1/JNK signaling pathway in mice with traumatic brain injury

Fig. 3

The effects of Cl-amidine treatment on BBB disruption after TBI. A Representative horizontal image of brains after EB injection and quantitative analysis of EB leakage intensity. *p < 0.05, **p < 0.01, ***p < 0.001, n = 6 per group. B Representative images and quantitation of IgG extravascular deposits (green). Capillaries were stained with CD31 (white). Nuclei were stained with DAPI (blue). Scale bar = 10 μm, *p < 0.05, ***p < 0.001, n = 6 per group. C Representative images of double immunofluorescence staining of ZO-1(red) and endothelial cells (CD31, green) and quantification of fluorescence intensity analysis of ZO-1 (relative to CD31) at 3 days after TBI. Nuclei were stained with DAPI (blue). Scale bar = 100 μm. *p < 0.05, ***p < 0.001, n = 6 per group. D Representative western blot bands and densitometric quantification of ZO-1, VE-cadherin, Occludin, and IgG at 3 days after TBI. *p < 0.05, **p < 0.01, ***p < 0.001, n = 6 per group

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Journal of Neuroinflammation

ISSN: 1742-2094