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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Inhibition of neutrophil extracellular trap formation ameliorates neuroinflammation and neuronal apoptosis via STING-dependent IRE1α/ASK1/JNK signaling pathway in mice with traumatic brain injury

Fig. 4

The effects of Cl-amidine treatment on microglia/macrophage activation, neutrophil, and macrophage infiltration, and the expression of IL‑1β at 3 days after TBI. A Representative image of immunofluorescence staining of Iba-1 (green) and quantitative analysis of Iba-1-positive microglia at 3 days after TBI. Nuclei were stained with DAPI (blue). ***p < 0.001, n = 6 per group. Scale bar = 100 μm. B Representative image of immunofluorescence staining of F4/80 (green) and quantitative analysis of F4/80-positive macrophages at 3 days after TBI. Nuclei were stained with DAPI (blue). ***p < 0.001, n = 6 per group. Scale bar = 100 μm. C Representative image of double immunofluorescence staining of MPO (green) and CD31 (grey), and quantitative analysis of MPO-positive neutrophils at 3 days after TBI. Nuclei were stained with DAPI (blue). **p < 0.01, ***p < 0.001, n = 6 per group. Scale bar = 100 μm. D Representative image of immunofluorescence staining of IL-1β (green) and quantitative analysis of IL-1β-positive cells at 3 days after TBI. Nuclei were stained with DAPI (blue). ***p < 0.001, n = 6 per group. Scale bar = 100 μm

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Journal of Neuroinflammation

ISSN: 1742-2094