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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Inhibition of neutrophil extracellular trap formation ameliorates neuroinflammation and neuronal apoptosis via STING-dependent IRE1α/ASK1/JNK signaling pathway in mice with traumatic brain injury

Fig. 6

Effects of Cl-amidine treatment on neuronal death at 3 days after TBI. A Representative image of NeuN immunostaining in the ipsilateral CTX, CA1, CA3, and DG regions at 3 days after TBI. Nuclei were stained with DAPI (blue). Scale bar = 200 μm. B Ipsilateral brain areas (rectangles) in the CTX, CA1, CA3, and DG where images in A were captured. Scale bar = 1 mm. C–F Quantitative analysis of NeuN‑immunopositive neurons in the ipsilateral CTX (C), CA1(D), CA3 (E), and DG (F) regions at 3 days after TBI. G Representative image of the FJC (green) staining in the CTX and CA1 at 3 days after TBI. Nuclei were stained with DAPI (blue). Scale bar = 100 μm. H, I Quantitative analysis of FJC -positive cells in the CTX (H) and CA1 (I) at 3 days after TBI. ***p < 0.001, n = 6 per group. J Representative images of TUNEL (green) co-localization with neurons (NeuN, red) in the CTX and CA1 at 3 days after TBI. Nuclei were stained with DAPI (blue). Scale bar = 100 μm. K, L Quantitative analysis of TUNEL-positive neurons in the CTX (K) and CA1 (L) at 3 days after TBI. **p < 0.01, ***p < 0.001, n = 6 per group

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Journal of Neuroinflammation

ISSN: 1742-2094