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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Inhibition of neutrophil extracellular trap formation ameliorates neuroinflammation and neuronal apoptosis via STING-dependent IRE1α/ASK1/JNK signaling pathway in mice with traumatic brain injury

Fig. 8

STING agonist abolished the neuroprotective effects of Cl-amidine via IRE1α/ASK1/JNK signaling pathway after TBI. A Representative double immunofluorescence staining for NeuN (green) and pIRE1α (red) and quantitative analyses of pIRE1α+ neuron in the contused cortex at 3 days after TBI. Nuclei were stained with DAPI (blue). Scale bar = 100 μm. **p < 0.01, ***p < 0.001, n = 6 per group. B Representative double immunofluorescence staining for Iba-1 (green) and pIRE1α (red) and quantitative analyses of pIRE1α+ microglia in the contused cortex at 3 days after TBI. Nuclei were stained with DAPI (blue). Scale bar = 100 μm. **p < 0.01, ***p < 0.001, n = 6 per group. C Representative western blot bands and densitometric quantification of pIRE1α, pASK1, and pJNK in the contused cortex after TBI. *p < 0.05, **p < 0.01, ***p < 0.001, n = 6 per group

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Journal of Neuroinflammation

ISSN: 1742-2094