Fig. 10
From: Cell-specific NFIA upregulation promotes epileptogenesis by TRPV4-mediated astrocyte reactivity
Schematic diagram of NFIA-TRPV4 signal mediating astrocyte reactivity to promote 4-AP induced epilepsy in mice. (left) In exposure of 4-AP, NFIA in astrocytes is upregulated and binds to TRPV4 promoter to increase TRPV4 expression, thereby remodeling astrocyte reactivity and increasing the expression of its proinflammatory cytokines, aggravating neuroinflammation to increase aberrant neuronal discharge, epileptic symptom and neuronal damage. (right) NFIA deficiency in astrocytes downregulates TRPV4 expression and inhibits the release of proinflammatory cytokines from reactive astrocyte, therefore attenuating neuroinflammation to improve epileptic symptoms and neuronal loss