Fig. 2
From: Cell-specific NFIA upregulation promotes epileptogenesis by TRPV4-mediated astrocyte reactivity
NFIA knockdown prevents hippocampal neurons from 4-AP increased excitation. A Scheme of animal preparation for whole-cell patch recording experiment. Representative curves (B) of neuronal AP discharge evoked by step currents from 0 to 180 pA with 20 pA increment in whole-cell recording and the analysis of resting membrane potential (C) and AP number (D) of CA1 pyramidal neurons in hippocampal slices from the mice with si. NC/si. NFIA delivery and ip. 4-AP/saline (si.NC: n = 11, si.NFIA: n = 8, si.NC + 4-AP: n = 9, si.NFIA + 4-AP: n = 12, *P < 0.05, **P < 0.01, ****P < 0.0001, One-way ANOVA)