Fig. 5
From: Cell-specific NFIA upregulation promotes epileptogenesis by TRPV4-mediated astrocyte reactivity
Astrocytic NFIA and TRPV4 expression are upregulated in TLE patients and 4-AP-induced seizure mouse model. Representative confocal images (Ai) of TRPV4 and NFIA in hippocampal tissues from the TLE patients who had surgery and the deceased without TLE as a control, and three visual fields (0.5 mm2 per visual field) in each human specimen were applied for the fluorescence intensity analysis of Aii NFIA and Aiii TRPV4 (human TLE: n = 5, Human Ctrl: n = 6, * P < 0.05, **P < 0.01, Student’s t test). Representative confocal immunofluorescent images Bi of TRPV4 and NFIA, and the fluorescence intensity analysis of Bii NFIA and Biii TRPV4 in hippocampal tissues from the mice with ip. 4-AP or saline (n = 6 for each group, **P < 0.01, Student’s t test)