Fig. 3From: Impairing Gasdermin D-mediated pyroptosis is protective against retinal degenerationGsdmd−/− CRISPR knockout characterisation. A Schematic of murine GSDMD with CRISPR G9 target region highlighted, and corresponding amino acid sequence decoded. B Retinal gene expression panel of inflammatory genes, as measured by qRT-PCR, in WT and Gsdmd−/− mice following 5d PD (p > 0.05, N = 4). C IL-1β released from WT and Gsdmd−/− retina post-5-day PD as measured by ELISA (p > 0.05, N = 4). D, E Representative image of GSDMD immunohistochemistry in WT and Gsdmd−/− retinas post-5day PD. Scale bar = 50 μmBack to article page