Fig. 5

Myelin disruption/dismantling and scavenging in CD47-deleted Schwann cells exceed disruption/dismantling and scavenging in CD47-expressing Schwann cells. Schwann cells were randomly sampled in micrographs of cross sections of Wallerian degenerating nerves from wild type (WT) and CD47−/− mice taken on days 2 to 2.5 after surgery. Nerves were sampled 5 to 6 mm distal to but not including lesion sites (e.g., Fig. 4). Box and whisker plots of (A) percent of Schwann cells presenting disrupted myelin (e.g., Fig. 4B–D) and (B) percent of Schwann cells that contain myelin debris in their cytoplasm (e.g., Fig. 4F). In (A), total of 673 WT and 874 CD47−/− Schwann cells were sampled, respectively, in 4 WT and 6 CD47−/− injured nerves. In (B), total of 673 WT and 874 CD47−/− Schwann cells were sampled, respectively, in 5 WT and 6 CD47−/− injured nerves. Significance of difference between WT and CD47−/− mice is *p < 0.05 and **p < 0.01, by Mann–Whitney test