Skip to main content
Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Recombinant Slit2 suppresses neuroinflammation and Cdc42-mediated brain infiltration of peripheral immune cells via Robo1–srGAP1 pathway in a rat model of germinal matrix hemorrhage

Fig. 7

Effects of recombinant Slit2 on brain peripheral immune cells infiltration at 5 days after GMH. A Representative microphotograph and quantitative analysis of immunofluorescence staining showed that fewer MPO positive neutrophils were visualized in the brain tissue of GMH + rSlit2 group compared to GMH + Vehicle group. Scale bar = 100 μm; Western blotting analysis showed that recombinant Slit2 down-regulated brain neutrophil marker MPO (B) and macrophage marker CD68 (C) after GMH and such effects were reversed by rRobo1 co-administration. N = 6/group. Mean ± SEM. ANOVA, Tukey. *P < 0.05 vs. Sham, #P < 0.05 vs. GMH + Vehicle, @P < 0.05 vs, GMH + rSlit2

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094