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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: Recombinant Slit2 suppresses neuroinflammation and Cdc42-mediated brain infiltration of peripheral immune cells via Robo1–srGAP1 pathway in a rat model of germinal matrix hemorrhage

Fig. 9

Western blotting analysis of brain Robo1 and srGAP1 expressions at 5 days after GMH. A Brain expressions of Robo1 and srGAP1 were significantly increased after GMH compared to Sham, which were further elevated in GMH + rSlit2 group. Recombinant Robo1 co-administration with rSlit2 reversed the upregulation effects of rSlit2 of on Robo1 and srGAP1. B Brain srGAP1 expression was increased in GMH + rSlit2 and GMH + Slit2 + scrambled siRNA groups compared to GMH. The administration of srGAP1 siRNA decreased the expression of srGAP1, but not Robo1 in brain after GMH. N = 6/group. Mean ± SEM. ANOVA, Tukey. *P < 0.05 vs. Sham, #P < 0.05 vs. GMH + Vehicle, @P < 0.05 vs. GMH + rSlit2, &P < 0.05 vs. GMH + rSlit2 + srGAP1 siRNA

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Journal of Neuroinflammation

ISSN: 1742-2094