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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Inhibition of UTX/KDM6A improves recovery of spinal cord injury by attenuating BSCB permeability and macrophage infiltration through the MLCK/p-MLC pathway

Fig. 4

Endothelial-specific UTX knockout enhances neurological recovery in mice after SCI. a, b Distribution of the BMS scores and BMS sub-scores in UTXf/f and UTX−/− groups at pre-surgery and after SCI throughout the 56-day period. n = 12 per group. c Typical digital photographs of the gait analysis of the mice in UTXf/f and UTX−/− groups at sham and on days 56 pre-SCI. Forelimbs: blue dyes, hindlimbs: red dyes. d, e Quantitative evaluation of the width and length of gait per a step in c. n = 12 per group. f Representative images of motor-evoked potential (MEP) in sham, in UTXf/f and UTX−/− groups at 56-day post-SCI. g Quantitative evaluation of the amplitude of MEPs in f. n = 6 per group. Data are represented as mean ± SEM. ns P > 0.05, *P < 0.05, **P < 0.01

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