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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Repeated sleep deprivation decreases the flux into hexosamine biosynthetic pathway/O-GlcNAc cycling and aggravates Alzheimer’s disease neuropathology in adult zebrafish

Fig. 8

Suppression of RSD-induced astrocyte activation and Aβ accumulation by overexpression of OGT. An vOGT virus was injected into the brains of zebrafish. Representative confocal images (40×) of DAPI (blue), GFAP (A and B, green), Aβ (C, green), and merged immunofluorescence staining in the Dl or Vd regions of zebrafish telencephalon are displayed. Enlarged images are presented in the white boxes. The graphs represent the quantitative results for each antibody with normalization by the DAPI levels (n = 3/group). For statistical analysis, the Kruskal–Wallis test with the original FDR of Benjamini and Hochberg was performed (*p < 0.05,  **p < 0.01 versus Con, ##p < 0.01 versus SD or RSD)

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Journal of Neuroinflammation

ISSN: 1742-2094