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Table 2 Demographic characteristics of participants undergoing clinical and neuropsychological assessments

From: Microglial activation, tau and amyloid deposition in TREM2 p.R47H carriers and mild cognitive impairment patients: a multi-modal/multi-tracer PET/MRI imaging study with influenza vaccine immune challenge

 

Clinical controls

(n = 29)

MCI

(n = 11)

TREM2 p.R47H

(n = 12)

Age

(median + IQR)

73.1

(66.5–76.4)

71.6

(65.8–77.5)

64.9

(60.0–69.4)a,b

Sex

(male/female)

10 / 19

8 / 3

6 / 6

Education

(median + IQR)

18

(16.5–20)

14

(12–18)

18

(17.3–20)b

APOEε4

(carrier/non-carrier)

8 / 21

4 / 7

2 /10

MoCA

(median + IQR)

28.0

(27.0–30.0)

25.0

(23.0–26.0)

29.0

(26.5–30.0)b

  1. APOEε4 carrier refers to the number with ≥ 1 ε4 allele
  2. IQR  interquartile range, MCI  mild cognitive impairment, MoCA  Montreal Cognitive Assessment
  3. aTREM2 p.R47H carrier significant versus controls; P < 0.05
  4. bTREM2 p.R47H carrier significant versus MCI group; P < 0.05
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Journal of Neuroinflammation

ISSN: 1742-2094