Fig. 4

Molecular patterning of rmProperdin-treated primary microglia. a Volcano plot showing the upregulated and downregulated DEGs (∣log2FC∣ > 1, FDR < 0.05) between 8 µg/ml rmProperdin-treated primary microglia and control microglia. b Heatmap of genes differentially expressed between rmProperdin-treated microglia and unstimulated microglia. c GSEA plots showing that the significantly enriched gene sets positively correlated with rmProperdin-treated microglia were “TNF signaling pathway”, “NF-kappa B signaling pathway” and “C-type lectin receptor signaling pathway”. d Scatter plot of KEGG pathway enrichment analysis of DEGs in microglia treated with rmProperdin or not